This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The RNAseq data is available in GEO, with the accession number GSE166681.įunding: Funding was provided by: Academy of Finland (MetaStem Center of Excellence funding 312439) to VH, Sigrid Juselius Foundation to VH, Novo Nordisk Foundation (NNF18OC0034406 and NNF19OC0057478) to VH, Jane and Aatos Erkko Foundation to VH, and Integrative Life Science Doctoral Program to NL. Received: FebruAccepted: OctoPublished: October 11, 2021Ĭopyright: © 2021 Kokki et al. Barsh, HudsonAlpha Institute for Biotechnology, UNITED STATES (2021) Metabolic gene regulation by Drosophila GATA transcription factor Grain. Collectively, our study provides evidence for the role of a metazoan GATA transcription factor in nutrient-responsive metabolic gene regulation in vivo.Ĭitation: Kokki K, Lamichane N, Nieminen AI, Ruhanen H, Morikka J, Robciuc M, et al. Consistently with these differential tissue-specific roles, Grain deficient larvae display delayed development on high sugar diet, while showing deregulated central carbon and lipid metabolism primarily on low sugar diet. On the other hand, grain displays strong constitutive expression in the anterior midgut, where it drives lipogenic gene expression also under low sugar conditions. grain expression is activated by sugar in Mondo-Mlx-dependent manner and it contributes to sugar-responsive gene expression in the fat body. De novo motif prediction uncovered a significant over-representation of GATA-like motifs on the promoters of sugar-activated genes in Drosophila larvae, which are regulated by Grain, the fly ortholog of GATA1/2/3 subfamily. Here we identify a role for Drosophila GATA TF Grain in metabolic gene regulation under both low and high sugar conditions. TFs that correspondingly control sugar responsive metabolic genes under conditions of low dietary sugar remain, however, poorly understood. In Drosophila, dietary sugars activate transcription factors (TFs), such as Mondo-Mlx, Sugarbabe and Cabut, which control metabolic gene expression to mediate physiological adaptation to high sugar diet. Sendmail-cf-8.14. has missing requires of sendmail = ('0', '8.14.4', '8.Nutrient-dependent gene regulation critically contributes to homeostatic control of animal physiology in changing nutrient landscape. Your transaction was saved, rerun it with: yum load-transaction /tmp/yum_save_tx ** Found 3 pre-existing rpmdb problem(s), 'yum check' output follows:įrontpage-2002-SR1.2.i386 has missing requires of libexpat.so.0 Yum -y update ERROR with rpm_check_debug vs depsolve: !! Please visit for help with this error. Since EasyApache was unable to resolve it automatically you should: 1) Manually run the failed YUM command (shown above) via SSH 2) See if your particular error is addressed at 3) Resolve the YUM problem manually 4) Re-run EasyApache !! This is the command that failed: yum -y install gettext automake19 libstdc++.x86_64 libpng-devel readline-devel openssl libpng-dev zlib-devel autoconf261 libidn-devel gmake libidn libXpm openssl-devel automake coreutils patch libltdl3-devel libltdl libopenssl0.9.7-static-devel readline-dev libtool-ltdl-devel libXpm-devel sed libXpm-dev lsof krb5-dev flex glibc-dev expat-dev krb5-devel libstdc++-devel.圆4_64 xorg-x11-devel libtool-ltdl libssl-dev pam-devel libopenssl0-devel zlib1-devel expat-devel libopenssl0-dev glibc-devel expat gcc-c++ zlib bison libjpeg-devel libtool-libltdl-devel libtool openssl-dev libopenssl0 libz-devel libjpeg-dev pam-dev fileutils libltdl-devel libopenssl0.9.7-devel e2fsprogs-devel ca_root_nss make libstdc++-dev.x86_64 libX11-devel libstdc++-devel.x86_64 gd cpp xorg-x11-dev gcc ssl-dev lex autoconf !! !! The server’s system package manager, ‘YUM’, failed. I keep getting the following error on easy appache
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